TB-500

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

TB-500 is a synthetic heptapeptide fragment corresponding to the actin-binding domain of Thymosin Beta-4 (Tβ4), a 43-amino acid endogenous protein involved in actin sequestration, cytoskeletal dynamics, and cell migration. The active fragment — Ac-LKKTETQ — retains the core actin-binding motif of full-length Tβ4 and is used as a pharmacological research tool for studying G-actin sequestration, cell motility signaling, and Tβ4-mediated transcriptional regulation in vitro. TB-500 is studied in the context of cytoskeletal biology, angiogenic signaling, and tissue-repair-associated molecular pathways.

SpecificationA

• Form: Lyophilized Powder

• Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)

• CAS: 77591-33-4

• Molecular Weight: 831.0 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

TB-500 functions through G-actin sequestration via the LKKTET motif, which is the primary actin-binding domain of full-length Thymosin Beta-4 and is responsible for inhibiting actin polymerization — a mechanism studied extensively in the context of cell migration, lamellipodia formation, and cytoskeletal remodeling. Published research has examined TB-500 in the context of ILK (integrin-linked kinase) pathway activation, VEGF-mediated angiogenesis, and NF-κB signaling in endothelial and fibroblast cell models. It is also studied for its interactions with transcription factor MRTF-A (myocardin-related transcription factor A), which links actin dynamics to gene expression regulation. The acetylated N-terminus is a structural feature critical to its actin-binding properties and distinguishes it from non-acetylated analogs used in comparative assay contexts.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the TGA.

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Astralis Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.