What is GHK-Cu?
GHK-Cu (Copper Peptide GHK-Cu) is a naturally occurring tripeptide — glycyl-L-histidyl-L-lysine — bound to a copper ion. First isolated from human plasma in 1973, it is found in blood, saliva, and urine, and plays a critical role in wound healing, skin regeneration, and tissue remodelling. Plasma concentrations of GHK-Cu decline significantly with age, correlating with reduced regenerative capacity.
Mechanism of Action
GHK-Cu operates through several interconnected pathways. It stimulates collagen, elastin, and glycosaminoglycan synthesis, directly improving skin structure and elasticity. It activates antioxidant enzymes, reduces oxidative stress, and modulates over 4,000 human genes — upregulating tissue repair pathways and downregulating inflammatory and cancer-related genes. Its copper-chelating properties also support enzymatic activity critical to connective tissue integrity.
Key Research Applications
- Skin Regeneration: Demonstrated ability to increase skin thickness, reduce fine lines and wrinkles, and improve skin density and firmness.
- Wound Healing: Accelerates healing of wounds, burns, and surgical incisions by promoting fibroblast proliferation and collagen synthesis.
- Hair Growth: Research indicates GHK-Cu stimulates hair follicle size and growth, with potential applications in androgenic alopecia.
- Anti-Inflammatory: Reduces pro-inflammatory cytokines and oxidative damage, supporting systemic and localised recovery.
- Neuroprotection: Emerging evidence suggests GHK-Cu may support nerve regeneration and cognitive function.
Important Notes
GHK-Cu is sold strictly for research purposes. All information provided is based on preclinical and in vitro studies. This content is not intended as medical advice. Consult a qualified healthcare professional before use.