Retatrutide

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

RT is a synthetic acylated peptide functioning as a triple receptor agonist at the glucagon-like peptide-1 (GLP-1) receptor, glucose-dependent insulinotropic polypeptide (GIP) receptor, and glucagon (GCG) receptor. It represents a next-generation incretin-based research compound designed to probe the combined physiological effects of simultaneous tri-receptor activation on metabolic homeostasis. RT is studied in preclinical research contexts involving energy expenditure, hepatic lipid metabolism, insulin sensitivity, and the interplay between incretin and glucagon signaling axes.

Specifications

• Form: Lyophilized Powder

• CAS: 2381089-83-2

• Molecular Weight: 4,969.6 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

RT activates GLP-1R, GIPR, and the glucagon receptor (GCGR) — three class B GPCRs involved in distinct but overlapping metabolic regulatory pathways including insulin secretion, gluconeogenesis suppression, lipolysis, and thermogenesis. Research with RT as a pharmacological probe has examined the additive and synergistic effects of tri-receptor co-activation on hepatic glucose production, adipose tissue fatty acid oxidation, and hypothalamic energy sensing circuits. The inclusion of GCGR agonism distinguishes RT from dual incretin agonists and enables research into how glucagon receptor signaling modulates outcomes when combined with incretin receptor co-stimulation. It is also studied in the context of non-alcoholic fatty liver disease (NAFLD) models and lipid clearance mechanisms in vitro.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the TGA.

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Astralis Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.